Increasing number of poorly water soluble drugs has gained recognition in recent drug development. These drugs lack the ability to go into solution and it is sometimes a more important limitation for its overall rate of absorption than its ability to permeate the intestinal mucosa. Hence it would be extremely useful to have a predictive in vitro dissolution test which correlates with in vivo absorption. Such kind of test could be used when screening new formulations as well as changes in existing formulations with regard to their impact on bioavailability, Pharmaceutical industries and scientists face some challenges to develop such meaningful in vitro dissolution. The present study is an overview on the approaches like simulation of the in vivo gastrointestinal physiology with in vitro dissolution testing methods. These approaches include media composition using bile salts and lipoproteins, changing physicochemical properties which influence drug dissolution, effect of preprandial and postprandial state. Out of the aforementioned strategies use of biorelevant media is the most preferred one. There are many ways to develop the biorelevant media like varying the composition of bile salts and lecithin. Apart from these, surfactant media and novel pH adjusted biphasic media have been discussed. It was found that optimization of biorelevant media is necessary to achieve perfect correlation, but it is unstable and costly. Hence surfactant media and novel pH adjusted biphasic media are better to use out of which biphasic media is cost effective and reduces the money and wastage of time for industries.
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